CRISPR-CAS9 IN CANCER AND ITS FUTURE PROSPECTS: A REVIEW
by Khushi Yadav
Abstract – Cancer is a genetic disease caused by a series of genomic and epigenomic aberrations. In recent times, Cas9-associated Clustered Repetitive Interspaced Short Palindromic Repeats (CRISPR) has gained the worldwide attention of scientists as a versatile gene editing technology. Its extensive use in cancer therapeutics has also achieved tremendous success. However, despite its advances, several challenges such as off-target effects, editing efficiency, and edited cell toxicity remain to be addressed to fully realize its potential. This systematic review aims to assess the current and future applications of CRISPR-Cas9 in cancer therapy, while focusing on the challenges encountered in its clinical applications.